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Pfizer Vaccine seems to be Less Effective on Obese People

Scientists say that the Pfizer vaccine may be less effective in protecting obese people from COVID-19. According to a report on Medrxiv, the pre-print server, Rome researchers found a weaker antibody response was generated in obese people even after two vaccine doses.

The Guardian reported, the study has not been peer-reviewed. It evaluated the effect of the vaccine on 248 health care workers after seven days of the final dose. According to the National Cancer Institute Regina Elena researchers, people with a body mass index (BMI) over 30 are considered obese.

Compared to the people who have healthy body weight, the obese people produced about half the antibodies. Although, the current level of antibodies required to neutralize the virus is unknown. Inoculation efforts may be hindered with reduced antibody response is what experts fear.

The team also said that the findings highlighted the important implications of vaccine strategies for obese people. The study’s author wrote, “Since obesity is a major risk factor for morbidity and mortality for patients with Covid-19, it is mandatory to plan an efficient vaccination program in this subgroup.”

An option to consider is to give one extra shot or a more potent dose of the Pfizer vaccine. The researchers say that even though further studies are required, an extra dose of the vaccine may do the task. This can be an option to evaluate, according to researchers.

The researchers wrote, “If our data was to be confirmed by larger studies, giving obese people an extra dose of the vaccine or a higher dose could be options to be evaluated in this population.”

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